C-O Bond Formation By Arene C-H Activation Via Metal-Catalyzed Oxidation

This chapter highlights significant achievements in metal-catalyzed selective oxidation processes of arene C-H bonds to construct C-O bonds. A directing group is usually required to achieve high ortho- regioselectivity. Various functional groups have been fruitfully exploited as the directing groups for the acyloxylation, alkoxylation, hydroxylation, and intramolecular C-O cyclization of arenes by the palladium-, copper-, and ruthenium-catalyzed C-H activation. These transition-metal-catalyzed C-H/C-O processes can be efficiently achieved by utilizing either a monodentate or bidentate directing group.[GRAPHICS].