Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY(2022)
摘要
TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the WHO grading led to better patient prognostication by improved prediction of recurrence. Our results support implementation of TERTp-mut into diagnostics and classification of meningiomas.
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关键词
promoter mutations,prognostication
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