Hepatocyte cholesterol content modulates glucagon receptor signalling

Emma Rose McGlone,T Bertie Ansell, Cecilia Dunsterville,Wanling Song,David Carling,Alejandra Tomas,Stephen R Bloom,Mark S P Sansom,Tricia Tan,Ben Jones

Molecular Metabolism（2022）

引用 3|浏览21

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摘要

•Hepatic cholesterol accumulation induces glucagon resistance.•Cholesterol binding sites on the glucagon receptor differ in the active state.•Increased membrane cholesterol may directly induce glucagon resistance in NAFLD.

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关键词

Glucagon,Glucagon receptor,Cholesterol,Cell membrane,Non-alcoholic fatty liver disease,Type 2 diabetes mellitus

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