Characterizing impact of positive lymph node number in endometrial cancer using machine-learning: A better prognostic indicator than FIGO staging?

•Number of involved lymph nodes provides improved prognostic value compared to the existing FIGO staging system.•Number of involved nodes provides predictive value to response to adjuvant treatment in endometrial cancer.•Machine learning algorithms can be used to identify prognostic thresholds.•Future staging systems for endometrial cancer should consider incorporating nodal burden.