Synthesis of 4-methylvaleric acid, a precursor of pogostone, involves a 2-isobutylmalate synthase related to 2-isopropylmalate synthase of leucine biosynthesis
biorxiv(2021)
摘要
One Sentence Summary We describe a novel enzyme, 2-isobutylmalate synthase, that is related to 2-isopropylmalate synthase and is able to efficiently convert 4-methyl-2- oxovalerate to 2-isobutylmalate, a key intermediate in the synthesis of the pogostone precursor 4-methylvaleric acid.
### Competing Interest Statement
The authors have declared no competing interest.
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关键词
2-isobutylmalate, 2-isobutylmalate synthase, 2-isopropylmalate synthase, 4-methylvaleric acid, branched-chain fatty acid, Pogostemon cablin, pogostone, alpha-ketoacid elongation pathway
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