Plasma Contains Ultra-short Single-stranded DNA in Addition to Nucleosomal cfDNA
biorxiv(2021)
摘要
Plasma cell-free DNA is a widely used biomarker for diagnostic screening. We introduce uscfDNA-seq, a single-stranded cell-free DNA NGS pipeline, which bypasses previous limitations to reveal a novel population of ultrashort single-stranded cell-free DNA in plasma with a modal size of 50nt. This species of cfDNA aligns predominantly to the nuclear genome and could potentially be used for novel biomarker discovery.
### Competing Interest Statement
David Wong is a consultant to GSK, Mars-Wrigley, Colgate Palmolive and has equity in Liquid Diagnostics LLC.
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关键词
dna,plasma,ultra-short,single-stranded
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