In-Depth Analysis of Bacillus anthracis 16S rRNA Genes and Transcripts Reveals Intra- and Intergenomic Diversity and Facilitates Anthrax Detection

Peter Braun,Fee Zimmermann,Mathias C. Walter,Sonja Mantel,Karin Aistleitner, Inga Stürz,Gregor Grass,Kilian Stoecker, Pedro H. Oliveira

MSYSTEMS（2022）

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摘要

For severe infectious diseases, precise pathogen detection is crucial for antibiotic therapy and patient survival. Identification of Bacillus anthracis, the causative agent of the zoonosis anthrax, can be challenging when querying specific nucleotide sequences such as in small subunit rRNA (16S rRNA) genes, which are commonly used for typing of bacteria.

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关键词

16S rRNA,Bacillus anthracis,fluorescence in situ hybridization,anthrax,digital PCR,genomics,pathogen detection

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