Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 isolates from Pennsylvania.

Ahmed M Moustafa,Colleen Bianco,Lidiya Denu,Azad Ahmed,Brandy Neide,John Everett,Shantan Reddy,Emilie Rabut,Jasmine Deseignora,Michael D Feldman,Kyle G Rodino,Frederic Bushman,Rebecca M Harris,Josh Chang Mell,Paul J Planet

biorxiv（2021）

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摘要

Rapid whole genome sequencing of SARS-CoV-2 has presented the ability to detect new emerging variants of concern in near real time. Here we report the genome of a virus isolated in Pennsylvania in March 2021 that was identified as lineage B.1.1.7 (VOC-202012/01) that also harbors the E484K spike mutation, which has been shown to promote "escape" from neutralizing antibodies in vitro

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