Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible SARS-CoV-2 variants’ spike protein: Analysis of the new UK and SA SARS-CoV-2 variants

Two SARS-CoV-2 variants showing increased transmissibility relative to the Wuhan virus have recently been identified. Although neither variant causes more severe illness or increased risk of death, the faster spread of the virus is a major threat. Using computational tools, we found that the new SARS-CoV-2 variants may acquire an increased transmissibility by increasing the propensity of its spike protein to expose the receptor binding domain. This information leads to the identification of potential treatments to avert the imminent threat of these more transmittable SARS-CoV-2 variants. Teaser The more infective SARS-CoV-2 variants may expose its Achilles Heel – an opportunity to reduce their spreading. ### Competing Interest Statement The authors have declared no competing interest. * ACE2 : Angiotensin converting enzyme 2 MOE : Molecular Operating Environment PDB : Protein Data Bank RBD : Receptor binding domain