Baicalein alleviates pyroptosis and inflammation in hyperlipidemic pancreatitis by inhibiting NLRP3/Caspase-1 pathway through the miR-192-5p/TXNIP axis
International Immunopharmacology(2021)
摘要
•Baicalein alleviates HP.•Baicalein inhibits pyroptosis and inflammation by upregulating miR-192-5p.•miR-192-5p targets TXNIP.•Silencing miR-192-5p or TXNIP overexpression abolishes baicalein’s effect.•Baicalein mitigates pyroptosis and inflammation in HP via the NLRP3/Caspase-1.
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关键词
Hyperlipidemic pancreatitis,Baicalein,miR-192-5p,TXNIP,Pyroptosis,Inflammation,NLRP3,Caspase-1
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