Baicalein alleviates pyroptosis and inflammation in hyperlipidemic pancreatitis by inhibiting NLRP3/Caspase-1 pathway through the miR-192-5p/TXNIP axis

Xiangyang Wang,Hua Cai,Zhiyuan Chen,Yu Zhang,Minghao Wu,Xiaoping Xu,Li Yang

International Immunopharmacology（2021）

引用 13|浏览11

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摘要

•Baicalein alleviates HP.•Baicalein inhibits pyroptosis and inflammation by upregulating miR-192-5p.•miR-192-5p targets TXNIP.•Silencing miR-192-5p or TXNIP overexpression abolishes baicalein’s effect.•Baicalein mitigates pyroptosis and inflammation in HP via the NLRP3/Caspase-1.

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关键词

Hyperlipidemic pancreatitis,Baicalein,miR-192-5p,TXNIP,Pyroptosis,Inflammation,NLRP3,Caspase-1

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