Pregabalin alleviates neuropathic pain via inhibition of the PKCε/TRPV1 pathway

Neuroscience Letters（2022）

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摘要

•Pregabalin alleviates the hyperalgesia induced by SNI.•Pregabalin decreases the expression of IL-1β and IL-6 in SNI rats.•Pregabalin significantly reduces the level of PKCε/TRPV1 and reactive astrocytes in SNI rats.

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关键词

PKCε,TRPV1,SNI,PWMT,GFAP,PGB,BIM Ⅰ,PMA,ANOVA,CCI

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