Mechanosensitivity of N-methyl-D-aspartate receptors (NMDAR) is the key through which amyloid beta oligomers activate them

Alzheimer's disease(AD)is one of the major forms of dementia,accounting for 60 to 80％of the cases of dementia,affecting approximately 50 million people worldwide,which is why it has become an object of great interest in both the medical and social fields(Source:Alzheimer's Association).