A Comparison of the Neuroprotective and Reactivating Efficacy of a Novel Bispyridinium Oxime K870 with Commonly Used Pralidoxime and the Oxime HI-6 in Tabun-Poisoned Rats.
Acta medica (Hradec Kralove)（2021）
Abstract
The newly synthesized oxime K870 is not a suitable replacement for commonly used oximes in the antidotal treatment of acute tabun poisonings because its neuroprotective efficacy is only slightly higher or similar compared to studied currently used oximes.
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Key words
acetylcholinesterase,functional observational battery,histopathology,neurotoxicity,oximes,rats,tabun
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