A nitroreductase-responsive near-infrared phototheranostic probe for in vivo imaging of tiny tumor and photodynamic therapy

Lihong Li,Lei Ding,Xueyun Zhang,Danning Wen,Min Zhang,Wen Liu,Haojiang Wang,Bin Wang,Lili Yan,Lixia Guo,Haipeng Diao

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy（2022）

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摘要

•The novel hypoxia-activated and nitroreductase-responsive probe has been developed.•The probe exhibits near-infrared fluorescent off-on response to nitroreductase.•The probe has been used to imaging endogenous nitroreductase of living cells.•The probe has been first used for in vivo imaging of tiny tumor as small as 6 mm3.•The probe possesses prominent photodynamic therapy efficacy in vitro and in vivo.

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关键词

Nitroreductase,Near-infrared fluorescence probe,Phototheranostic,Tiny tumor imaging,Photodynamic therapy

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