Direct and indirect activation of the adenosine triphosphate-sensitive potassium channel to induce spinal cord ischemic metabolic tolerance.

Yuki Ikeno,Christian V Ghincea,Gavriel F Roda,Linling Cheng,Muhammad Aftab,Xianzhong Meng,Michael J Weyant,Joseph C Cleveland,David A Fullerton,T Brett Reece

The Journal of thoracic and cardiovascular surgery（2021）

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摘要

Both direct and nitric oxide-dependent indirect activation of the mitochondrial adenosine triphosphate-sensitive potassium channel play an important role in pharmacologically induced motor function preservation.

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关键词

KATP channel,ischemia-reperfusion injury,nicorandil,spinal cord injury,spinal cord protection,thoracoabdominal aortic surgery

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