Randomized Controlled Trial of a Cognitive Intervention to Improve Memory in Heart Failure

•Randomized, controlled interventional trial in 256 patients with heart failure.•Measures: memory, working memory, instrumental activities of living, quality of life.•All treatment groups had significant improvements of cognitive measures over 8 months.•Computerized cognitive training did not significantly alter outcomes over controls.•Nurse enhancement and decreases in serum brain-derived neurotrophic factor were found.