SARS-CoV-2 variants with T135I nucleocapsid mutations may affect antigen test performance

Ming-Jr Jian,Hsing-Yi Chung,Chih-Kai Chang,Jung-Chung Lin,Kuo-Ming Yeh,Chien-Wen Chen,De-Yu Lin,Feng-Yee Chang,Kuo-Sheng Hung,Cherng-Lih Perng,Hung-Sheng Shang

International Journal of Infectious Diseases（2022）

Cited 37|Views25

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Abstract

•N protein mutations in the B.1.1.7 variant of concern may escape antigenic test detection.•Paired rapid antigen tests and molecular diagnostic methods are needed.•False-negative results could be rapidly corrected with RT-PCR.

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Key words

COVID-19,SARS-CoV-2,Rapid antigen test,B.1.1.7 variant,N protein

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