Evolutionary conservation and cell type specificity of nuclear compartments in the brain
Trends in Neurosciences(2022)
Abstract
In the cell nucleus, radial genome organization relative to the nuclear lamina exhibits both cell type–specific variability and evolutionarily conserved distribution. A recent study by Ahanger, Delgado et al. explores the in vivo spatial distribution of the genome in the brain and identifies conserved genomic localization across mammalian species that are correlated with gene expression states.
MoreTranslated text
Key words
spatial genome organization,lamin B,lamina-associated domain (LAD),speckle-associated domain (SPAD),human cortex
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined