Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1

Dear Editor, ABCD1,a member of the subfamily D of ABC transporters,participates in the transport of various fatty acid-CoA derivatives or very long-chain fatty acids (VLCFA) into the peroxisome and is essential for peroxisomal metabolism and lipid homeostasis.1 Dysfunction of human ABCD1 is associated with neurodegenera-tive diseases,including X-linked adrenoleukodystrophy (X-ALD).1 The molecular basis of substrate recognition and transport by human ABCD1 remains unknown.To date,four ABCD members have been identified in mammals.1 As exporters,ABCD1-3 transport fatty acid-CoA derivatives or VLCFA from the cytosol into peroxisomes for β-oxidation with substrate preferences.