Formal (3+1+1) Carboannulation of Morita-Baylis-Hillman Carbonates with Pyridinium Ylides: Access to Spiro-Cyclopentadiene Oxindoles
ORGANIC LETTERS(2021)
摘要
An efficient formal (3 + 1 + 1) carboannulation strategy of Morita-Baylis-Hillman (MBH) carbonates with pyridinium ylides was developed for constructing diversely functionalized Spiro-cyclopentadiene oxindoles. The reaction initiates with an S(N)2' olefination of MBH carbonates with pyridinium ylides. The in situ generated dienes then engage in a challenging (4 + 1) ylide carboannulation, which has been rarely reported before. The reaction features broad substrate scope as well as high chemo- and regioselectivity. (3 + 1 + 1) carboannulation products could be easily transformed into interesting Spiro-cyclopenta[c] furan oxindoles.
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关键词
pyridinium ylides,morita–baylis–hillman carbonates,carboannulation,spiro-cyclopentadiene
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