Letter to the editor regarding differentiating fat embolism from critical illness-associated cerebral microbleeds

•Fat embolism syndrome a complication of vaso-occlusive crisis in sickle cell disease•Critical illness associated cerebral microbleeds are rarely seen in patients after prolonged respiratory distress•Microhemorrhage of the deep white matter, basal ganglia, and thalami with diffusion restriction suggests fat embolism•Exchange transfusion improves mortality for fat embolism syndrome and sickle cell disease