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Grade 4 Neutropenia Secondary to Immune Checkpoint Inhibition - A Descriptive Observational Retrospective Multicenter Analysis.

Anne Zaremba,Rafaela Kramer, Viola De Temple,Stefanie Bertram,Martin Salzmann,Anja Gesierich,Lydia Reinhardt,Barouyr Baroudjian,Michael M Sachse,Gunhild Mechtersheimer,Douglas B Johnson,Alison M Weppler,Lavinia Spain,Carmen Loquai,Milena Dudda,Claudia Pföhler,Adriana Hepner,Georgina V Long,Alexander M Menzies,Matteo S Carlino,Céleste Lebbé,Tomohiro Enokida,Makoto Tahara,Paul J Bröckelmann,Thomas Eigentler,Katharina C Kähler,Ralf Gutzmer,Carola Berking,Selma Ugurel,Nadine Stadtler,Antje Sucker,Jürgen C Becker,Elisabeth Livingstone,Friedegund Meier,Jessica C Hassel, Dirk Schadendorf,Maher Hanoun,Lucie Heinzerling,Lisa Zimmer

Frontiers in oncology（2021）

Cited 7|Views35
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Abstract
Grade 4 neutropenia is a rare but potentially life-threatening side effect of ICI treatment. Most cases were sufficiently managed using G-CSF; however, adequate empiric antibiotic, antiviral, and antimycotic treatments should be administered if neutropenic infections are suspected. Immunosuppression using corticosteroids may be considered after other causes of neutropenia have been excluded.
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Key words
adverse events,hematotoxicity,immune checkpoint inhibition,malignant melanoma,neutropenia
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