Phenotype transition of fibroblasts incorporated into patient-derived oral carcinoma organoids.
Oral diseases（2023）
Abstract
We developed a robust strategy to study contact-dependent mechanisms underlying tumour-stromal interaction, and suggested that Notch activity contributes to biogenesis of OSCC-associated fibroblasts.
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Key words
cell-matrix interactions,fibroblasts activation,notch activity,oral squamous cell carcinoma,patient-derived organoid
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