Increased expression of Rho-associated protein kinase 2 confers astroglial Stat3 pathway activation during epileptogenesis

Li-Jia Song,Hua Zhang,Xiao-Peng Qu,Jun-Gong Jin,Chao Wang,Xue Jiang, Li Gao,Gang Li,Da-Li Wang,Liang-Liang Shen,Bei Liu

Neuroscience Research（2022）

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摘要

•ROCK2 overexpression reveals the occurrence of epilepsy.•Promoter hypomethylation resulted in ROCK2 overexpression.•ROCK2 activates astrocyte STAT3 pathway during epileptogenesis.

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关键词

AEDs,CNS,CDK,ChIP,EEG,FBS,FLAIR- FDG-PET,GTCS,GFAP,HRP,HS,IHC,Li-Pilo,MRI,MES,MTLE-HS,NeuN,OD,PTZ,qPCR,ROCK,SD,SE,TLE

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