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An improved HIV antigen/antibody prototype assay for earlier detection of acute HIV infection

Xiaoxing Qiu,Lori Sokoll,Thoai Duong Ly, Catherine Coignard,Susan H Eshleman,Phaedre Mohr, Clinton Huizenga,Priscilla Swanson,Gavin Cloherty,John Hackett

Journal of Clinical Virology（2021）

Cited 2|Views18
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Abstract
•Performance of a new HIV antigen/antibody prototype assay, HIV combo Next, was evaluated.•HIV combo next had the best LODs for WHO antigen standard and reference panels.•HIV combo next showed the most sensitive detection of acute HIV-infection.•HIV combo next detected all HIV staged and genotyped samples.•Specificity of the HIV combo next was 99.97% for blood donors.
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Key words
HIV antigen/antibody combination test,HIV antigen/antibody test,HIV genetic diversity,Acute HIV infection
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