Differential immunomodulation of human mesenchymal stromal cells from various sources in an inflammation mimetic milieu

●There are unique differences in the immunomodulatory properties of MSCs sourced from primitive and adult sources upon crosstalk with MNCs.●MSCs suppress the proliferation of mitogen-stimulated MNCs and modulate immune cells differentially, toward a more immune-suppressive phenotype.●There are a source-specific MSC-cytokine signatures upon interaction with immunocytes under mitogen-stimulated conditions.●This study gives scope for optimal use of MSCs from different sources for various indications in cellular therapy.