New ingenane and ingol diterpenoids from Euphorbia royleana .

Phytochemical investigation on the 95% EtOH extract of the Traditional Chinese Medicine (TCM) (Ba-wang-bian in Chinese) led to the isolation of 11 diterpenoids (-) and two triterpenoids ( and ). Among them, compounds and were new ingenane and ingol diterpenoids, respectively. Their structures were elucidated by a combination of spectroscopic analyses (1 D and 2 D NMR, HRMS, ECD, UV, and IR data) and chemical methods. Compounds and exhibited moderate cytotoxicities against human lung cancer cell line A549 with IC values of 14.84 ± 0.56 and 27.11 ± 1.65 µM, respectively.