The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
iScience(2021)
Abstract
Abstract We identify amino acid variants within dominant SARS-CoV-2 T-cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T-cells assessed by IFN-γ and cytotoxic killing assays. These data demonstrate the potential for T-cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T-cell as well as humoral immunity.
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Key words
Phylogenetics,Molecular biology,Immunology,Immune response,Virology
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