Intraoperative DNA methylation classification of brain tumors impacts neurosurgical strategy.

Luna Djirackor,Skarphedinn Halldorsson,Pitt Niehusmann,Henning Leske,David Capper,Luis P Kuschel,Jens Pahnke,Bernt J Due-Tønnessen,Iver A Langmoen,Cecilie J Sandberg,Philipp Euskirchen,Einar O Vik-Mo

Neuro-oncology advances（2021）

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摘要

Intraoperative nanopore sequencing combined with machine learning diagnostics was robust, sensitive, and rapid. This strategy allowed DNA methylation-based classification of the tumor to be returned to the surgeon within a timeframe that supports intraoperative decision making.

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关键词

DNA methylation,brain tumor,extent of resection,intraoperative diagnostics,nanopore

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