Highly aminated iron oxide nanoworms for simultaneous manufacturing and labeling of chimeric antigen receptor T cells

Wei Zhang,Hanmant Gaikwad,Ernest V Groman,Enkhtsetseg Purev,Dmitri Simberg,Guankui Wang

Journal of Magnetism and Magnetic Materials（2022）

引用 3|浏览15

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摘要

•Iron oxide nanoworms could contribute to CAR-T manufacturing and labeling in vitro.•CAR-T cytotoxicity to tumor cells is not affected by iron oxide nanoworms in vitro..•CAR-T cells labeled with iron oxide nanoworms could be tracked in vivo.

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关键词

CAR-T,Iron oxide,Nanoworm,Magnetic labeling,Leukemia,Cell trafficking

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