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Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized gamma-lactams

ORGANIC & BIOMOLECULAR CHEMISTRY(2021)

Cited 7|Views3
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Abstract
An efficient gold-catalyzed oxidative cyclization of amide-alkynes is developed. A series of functionalized gamma-lactams are easily accessed by employing this strategy. The tandem reaction proceeds through alkyne oxidation, carbene/alkyne metathesis, and donor/donor carbene oxidation.
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Key words
oxidative cyclization,gold-catalyzed,amide-alkynes
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