Diverse B-cell specific transcriptional contexts of the BCL2 oncogene in mouse models impacts pre-malignant development

Follicular lymphoma (FL) is the most common indolent form of non-Hodgkin lymphoma arising from malignant germinal center (GC) B-cells. The genetic hallmark that leads to the development of FL is the t(14:18) which occurs early in the bone marrow during B cell development, thereby placing the anti-apoptotic BCL2 gene under the direct control of the transcriptional enhancers from donwstream of immunoglobulin heavy chain locus (IgH 3RR) and leading to the constitutive expression of the BCL2 protein. To assess the impact of the BCL2 deregulation on B-cell fate and try to reproduce FL development in mice, two models were designed: the Igkappa-BCL2 (Knock in of the Bcl2 in the light chain Ig kappa locus) and the BCL2-3RR (transgene containing BCL2 and a micro-3RR from the IgH locus), both containing the full BCL2 promoter region. ### Competing Interest Statement The authors have declared no competing interest.