Prognostic value of malignant T cell-amplified sequence 1 in head and neck squamous cell carcinoma
BIOMARKERS IN MEDICINE(2021)
摘要
Aim: To explore the expression profile and prognostic value of MCTS1 in head and neck squamous cell carcinoma (HNSC). Materials & methods: This study used the data from TCGA to HNSC database, GEO database and the data and specimens collected from the patients in our hospital to conduct a comprehensive bioinformatic analysis of MCTS1 in HNSC. Results: MCTS1 was significantly upregulated. MCTS1 mRNA expression level is a potential prognostic biomarker for overall survival and recurrence-free survival. We revealed the potential interactions of MCTS1 with other molecules and potential relationship with ubiquitination, translation initiation and mRNA splicing in HNSC. Conclusion: MCTS1 was significantly upregulated in primary HNSC. The correlation of MCTS1 with poor prognosis suggested its potential as a prognostic marker for HNSC patients.
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关键词
bioinformatic analysis,head and neck cancer,MCTS1,oral squamous cell carcinoma,prognosis
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