Second Primary Head and Neck Malignancies in Patients With Prior Human Papilloma Virus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) Treated With Radiation

J F Canavan,S R Campbell, S Koyfman, N M Woody, B Matia,C A Reddy, E Ilori, D J Adelstein, J L Geiger, B B Burkey, L Schwartzman,E Lamarre,J Ku, B Prendes, R R Lorenz, J Scharpf

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS（2021）

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摘要

The risk of a second head and neck malignancy in survivors of HPV associated OPSCC is low, but as the incidence of HPV related OPSCC remains elevated and the likelihood of cure is excellent, secondary malignancy is an important long-term risk. Despite prior RT, consideration of post-operative re-irradiation is important as regional failure may carry a poor prognosis.

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neck malignancies,prior human papilloma virus,hpv,squamous cell carcinoma

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