Characterization of the Entire Metastatic Spectrum for Non-Small Cell Lung Cancer in the Immunotherapy Era

To our knowledge, this is the first study to characterize the anatomic disease spectrum in a modern cohort of advanced NSCLC. Most patients had 3 or fewer metastatic lesions, meeting a conservative definition of oligometastatic disease. However, many patients had multifocal thoracic disease. Technological radiotherapy approaches that can efficiently ablate multiple lesions in diverse anatomic locations will enable investigation of aggressive local therapy in a broad NSCLC population.