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Mechanism of Action of Tumor Treating Fields (TTFields) in Combination with Sorafenib for Treatment of Hepatocellular Carcinoma

S Davidi,A Shteingauz, S Jacobovitch,K Gotlib,C Tempel Brami,M Munster,E Zeevi,E Dor-On,R S Schneiderman,T Voloshin,A Haber,M Giladi,A Kinzel,U Weinberg,Y Palti

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS（2021）

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Abstract
The results demonstrate that TTFields and sorafenib each induce ER stress leading to autophagy in HCC, and when combined, the elevated stress increases cellular death, both in vitro and in vivo. The ongoing phase 2 HEPANOVA (NCT03606590) clinical trial will investigate the safety and efficacy of TTFields plus sorafenib in patients with unresectable, locally advanced HCC.
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tumor treating fields,hepatocellular carcinoma,sorafenib,ttfields
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