The Dosimetric Effect of MRI Positive-Contrast Markers vs. Negative-Contrast Fiducial Markers on Proton Radiation

L. Wang, F. Poenisch,J. Sanders, N. Sahoo,X.R. Zhu,J. Ma,S. Choi,Q.N. Nguyen,H. Mok, C. Tang, S.E. McGuire, K.E. Hoffman,S.J. Shah,S.J. Frank

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS（2021）

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摘要

C4 Nova MRI positive-contrast fiducial markers have the least proton dose perturbation effect compared with gold and carbon MRI negative-contrast markers. These data may serve as evidence for future clinical trials to study the benefit of MRI from treatment planning to delivery using positive MRI signal C4 Nova FM in preserving tumor control while decrease radiation related toxicities in patients with prostate cancer.

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