MRI Radiomic Features of Radiation Induced Cardiac Toxicity and the Effects of c-GAS/STING Signaling

We identified Cardiac MRI features that were associated with radiation induced damage. These may represent structural and/or functional changes in the left ventricle as a result of radiation induced inflammation and fibrosis. In this preliminary study, it is notable that only one of the two features associated with irradiation in wild type mice was significant in the radioresistant CGASstrain. Further studies are planned to determine how these imaging features correlate with inflammation, fibrosis, and functional impairment of the heart after radiation treatment. In addition to better understanding the physiology of radiation induced cardiac toxicity, MRI radiomic analysis after cardiac exposure to radiation could be explored for clinical application.