A Comparison of Outcomes in Early-Stage Breast Cancer After External Beam Radiotherapy, Endocrine Therapy, Both, or Neither: A Retrospective Cohort Study Across a Large Health System

RT yielded LRR equivalent to ET in this population, while the combination was superior to either treatment alone. For patients with early-stage ER+ breast cancer, a prospective randomized trial comparing RT to ET and evaluating quality of life (QoL) is needed. In light of new trial data, a five-day course of RT can be considered; this treatment may yield equivalent LRR and better QoL than a five-year course of ET.