Salvage regional therapy using hepatic artery infusion pump in unresectable chemotherapy resistant colorectal liver metastases

•Patients with unresectable hepatic metastatic disease who have failed standard chemotherapy, have limited options.•Our study showed a 6-month median PFS and a PR rate of 40% to HAIP in patients with CRLM-predominant disease.•Clinical benefits were noted in patients with both liver-limited disease and liver and small volume extrahepatic disease.•HAIP should be considered in liver-predominant chemotherapy-resistant colorectal cancer as a salvage modality.