An update on the clinical pharmacology of miltefosine in the treatment of leishmaniasis
International Journal of Antimicrobial Agents(2022)
摘要
•Miltefosine is currently the only oral drug available to treat the neglected tropical disease leishmaniasis.•All clinical pharmacokinetic and pharmacodynamic data for miltefosine in the treatment of leishmaniasis are summarized.•Several recent studies established exposure-response relationships for various miltefosine treatment regimens.•An overview is provided of pharmacokinetic targets predictive of clinical relapse and outcome.
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关键词
clinical pharmacology,Leishmaniasis,pharmacokinetics,pharmacodynamics,miltefosine
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