Cell Wall Stress Stimulates the Activity of the Protein Kinase StkP of Streptococcus pneumoniae, Leading to Multiple Phosphorylation

•The activity of protein kinase StkP is increased in response to cell wall stress, resulting in multiple phosphorylation sites.•Additional StkP targets may be involved in cell division and cell wall synthesis.•Cross-talk between StkP and WalRK TCS is uncovered.•Link between carbon metabolism and cell division is revealed.•Accumulation of Spx provides clues to disruption of cell wall homeostasis.