A study of the influence of lead pollution on the anticoagulant activity of Whitmania pigra based on pharmacodynamics and metabolomics research

Xiufen Chen,Xuemei Luo,Chaojie Yang,Jieqin Meng,Liangke Cheng,Luying Gao,Miao Xue,Yaojun Yang

Journal of Chromatography B（2021）

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摘要

•Lead pollution could reduce the anticoagulant activity of leech.•The mechanism of lead pollution on leech’s efficacy was studied by metabolomics.•Heavy metal pollution in planting and breeding of TCM should be taken seriously.

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关键词

Whitmania pigra Whitman (leech),Blood stasis syndrome,Coagulation function,Hemorheology,Metabolomics,UPLC-Orbitrap-MS

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