MicroRNA-124 acts as a positive regulator of IFN-β signaling in the lipopolysaccharide-stimulated human microglial cells

Justina Pajarskienė,Vytautas Kašėta, Kristina Vaikšnoraitė,Virginijus Tunaitis,Augustas Pivoriūnas

International Immunopharmacology（2021）

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摘要

•miR-124 suppresses TLR4 – NFκB signal transduction pathway in human microglia.•miR-124 increase LPS-dependent IFN-β expression.•miR-124 upregulates expression of CD14 in human microglia.

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关键词

miR-124,Microglia,IFN-β,NFκB,Inflammation

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