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Design and Rationale of a Phase 2 Study of NeurOtoxin (Botulinum Toxin Type A) for the PreVention of Post-Operative Atrial Fibrillation – The NOVA Study

Jonathan P Piccini,Anders Ahlsson,Paul Dorian,Marc A Gillinov,Peter R Kowey,Michael J Mack,Carmelo A Milano,Louis P Perrault,Jonathan S Steinberg,Nathan H Waldron, Lawrence M Adams,David B Bharucha,Mitchell F Brin,William G Ferguson,Stefano Benussi

American Heart Journal（2022）

Cited 10|Views35
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Abstract
The NOVA Study will test the hypothesis that injections of AGN-151607 will reduce the incidence of POAF and associated resource utilization. If demonstrated to be safe and effective, the availability of a one-time therapy for the prevention of POAF would represent an important treatment option for patients undergoing cardiac surgery.
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Key words
antiarrhythmic,atrial fibrillation,botulinum toxin,cardiac surgery,postoperative atrial fibrillation,study protocol
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