Variants in clock genes could be associated with lower risk of type 2 diabetes in an elderly Greek population

Xanthippi Tsekmekidou,Fotis Tsetsos,Theocharis Koufakis,Marianthi Georgitsi,Nikolaos Papanas,Dimitrios Papazoglou,Athanasios Roumeliotis,Stylianos Panagoutsos,Elias Thodis,Marios Theodoridis,Ploumis Passadakis,Efstratios Maltezos,Peristera Paschou,Kalliopi Kotsa

Maturitas（2021）

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摘要

•Variants within PPARA, PPARD, PKDREJ, VAMP2 and CLOCK could protect against type 2 diabetes.•Rs6744132, located between HES6 and PER2, is associated with higher risk of type 2 diabetes.•Carriers of the recessive allele in variants of PPARD are less susceptible to type 2 diabetes.

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关键词

Type 2 diabetes,Clock genes,Circadian rhythm,Elderly,Greek,Single nucleotide polymorphism

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