Elevated Foxo3a and Fas-ligand expression in human periapical granulomas as a potential treatment target.

Kae Ishii,Takahito Tamura,Keisuke Hatori,Kazuma Himi,Takeshi Nakamura,Yurika Toyama,Taiki Miyata,Osamu Takeichi

Oral diseases（2023）

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摘要

Phosphorylated Foxo3a may reduce IL-1β release by inhibiting apoptosis through FasL in periapical periodontitis and prevent exacerbation. Thus, Foxo3a is a potential therapeutic agent for periapical periodontitis.

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关键词

Fas-ligand,forkhead box transcription factor class o3a,healthy gingival tissue,inflammatory cell,interleukin-1β,periapical lesions

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