A Microbial World: Could Metagenomic Next-Generation Sequencing Be Involved in Acute Respiratory Failure?

Chunrong Huang,Hong Chen,Yongjie Ding,Xiaolong Ma,Haixing Zhu,Shengxiong Zhang,Wei Du,Hanssa Dwarka Summah,Guochao Shi,Yun Feng

Frontiers in cellular and infection microbiology（2021）

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摘要

mNGS outperformed the conventional method in the detection of MTB, bacteria, fungi, mycoplasma, and virus. Orotracheal intubation, T2DM, immunosuppression, and inflammatory markers were associated with a higher detection rate of bacteria, fungi, and virus by mNGS. In addition, ptNGS results were consistent with the detection of abundant bacteria, fungi, and mycoplasma in our specimens.

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关键词

acute respiratory failure,conventional methods,mNGS,microbial detection,ptNGS

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