SIRT6 inhibits endothelial-to-mesenchymal transition through attenuating the vascular endothelial inflammatory response

Lifang Chen,Guan Wang,Jianyu He,Xin Yang,Zihan Zheng,Ying Deng,Yizhen Liu,Danli Chen,Rong Lin,Weirong Wang

International Immunopharmacology（2021）

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摘要

•Inflammatory cytokines induced EndMT and down-regulated SIRT6 expression in HUVECs.•SIRT6 suppressed inflammation-induced EndMT.•Endothelium-specific SIRT6 knockout promoted EndMT in the carotid arteries of mice.•SIRT6 inhibited EndMT through attenuating vascular endothelial inflammation.

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关键词

SIRT6,Endothelial-to-mesenchymal transition,HUVECs,Inflammatory response

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