Mapping Vitamin B-6 Metabolism By Hydrazocest Magnetic Resonance Imaging

Emilie Marie Sophie Patit-Tha Brun,Nicholas David Calvert,Mojmír Suchý,Alexia Kirby,Gerd Melkus,Ruslan Garipov,Christina L Addison,Adam J Shuhendler

CHEMICAL COMMUNICATIONS（2021）

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摘要

A new CEST-MRI contrast agent, 2-HYNIC, capable of sensing aromatic aldehydes is reported. Pyridoxal 5 '-phosphate, a key Vitamin B-6 metabolite necessary for >140 biotransformations was mapped by CEST-MRI in vitro and in vivo in lung cancer. 2-HYNIC provided access to this key biomarker associated with a variety of human diseases.

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关键词

metabolism,vitamin,magnetic resonance imaging,magnetic resonance,hydrazocest

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